{"id":1307,"date":"2015-09-18T11:43:21","date_gmt":"2015-09-18T18:43:21","guid":{"rendered":"http:\/\/www.wou.edu\/chemistry\/?page_id=1307"},"modified":"2020-07-13T22:49:34","modified_gmt":"2020-07-14T05:49:34","slug":"patricia-flatt","status":"publish","type":"page","link":"https:\/\/wou.edu\/chemistry\/patricia-flatt\/","title":{"rendered":"Patricia Flatt"},"content":{"rendered":"<h1 id=\"fhp_titledept\"><span style=\"color: #000000\">Professor of Chemistry<strong><a href=\"https:\/\/wou.edu\/wp\/flattp\/files\/2018\/09\/flatt-3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-67 alignright\" src=\"https:\/\/wou.edu\/wp\/flattp\/files\/2018\/09\/flatt-3.jpg\" alt=\"\" width=\"303\" height=\"399\" \/><\/a><\/strong><\/span><\/h1>\n<h1><span style=\"color: #cc3131\"><strong>Contact<\/strong><\/span><\/h1>\n<div id=\"mainContent\" class=\"col-md-8 wou-menu-visible\">\n<h4><strong>Department of Chemistry<\/strong><\/h4>\n<p><strong>(503) 838-8644<\/strong> | <strong>e-mail:<\/strong> <span><a href=\"mailto:flattp@wou.edu\">flattp@wou.edu<\/a><\/span> |<strong> DFSC 209<\/strong><\/p>\n<h2><span style=\"color: #000000\"><strong>Courses Taught:<\/strong><\/span><\/h2>\n<ul>\n<li><span style=\"color: #000000\">CH104, 105, 106 Introductory Chemistry Series (General-Organic-Biochemistry)<\/span><\/li>\n<li><span style=\"color: #000000\">CH320 Introduction to Forensic Science<\/span><\/li>\n<li><span style=\"color: #000000\">CH322 Medicinal Chemistry and Pharmacology<\/span><\/li>\n<li><span style=\"color: #000000\">CH345 Introduction to Toxicology<\/span><\/li>\n<li><span style=\"color: #000000\">CH347 Integrative Medicinal Science<\/span><\/li>\n<li><span style=\"color: #000000\">CH420W Forensic Laboratory Techniques and Documentation<\/span><\/li>\n<li><span style=\"color: #000000\">CH445 Toxicology Laboratory Techniques<\/span><\/li>\n<li><span style=\"color: #000000\">CH450\/550 Biochemistry I<\/span><\/li>\n<li><span style=\"color: #000000\">CH450\/551 Biochemistry II<\/span><\/li>\n<li><span style=\"color: #000000\">CH452\/552 Biochemistry Lab<\/span><\/li>\n<\/ul>\n<h2><strong><span style=\"color: #000000\">Research Interests:<\/span><\/strong><\/h2>\n<p><span style=\"color: #000000\">I am interested in studying the biological activities and biosynthesis of natural products in marine and terrestrial ecosystems.\u00a0 Current project in the lab, include:<\/span><\/p>\n<ul>\n<li>The investigation of harmful algal blooms<\/li>\n<li>The nature of stromatolitic communities<\/li>\n<\/ul>\n<h2 class=\"contact-us-1\"><span><strong>Vitae:<\/strong><\/span><\/h2>\n<\/div>\n<p><strong>Appointments:<\/strong><\/p>\n<ul>\n<li><span><a href=\"https:\/\/www.wesd.org\/willamettepromise\">Willamette Promise<\/a><\/span> Chemistry Coordinator (2015 \u2013 present)<\/li>\n<li>Professor (2018 to present) Department of Chemistry, Western Oregon University, Monmouth, OR<\/li>\n<li>Associate Professor (2013 to 2018) Department of Chemistry, Western Oregon University, Monmouth, OR<\/li>\n<li>Assistant Professor (2008 to 2013) Department of Chemistry, Western Oregon University, Monmouth, OR<\/li>\n<li>Assistant Professor of Sr. Research (2003-2010) College of Pharmacy, Oregon State University, Corvallis, OR Education<\/li>\n<li>Postdoctoral Fellow, Marine Natural Products Research (2000-2003) College of Pharmacy, Oregon State University, Corvallis, OR.<\/li>\n<\/ul>\n<p><strong>Education:<\/strong><\/p>\n<ul>\n<li>Ph.D. in Biochemistry,Vanderbilt University,Nashville, TN. 1994-2000<\/li>\n<li>M.S. in Plant Ecology, University of Denver, Denver, CO. 1992-1994<\/li>\n<li>Bachelor of Science in Biology at University of Denver, Denver, CO. Magna Cum Laude. Minors in Chemistry and Geography.1988-1992<\/li>\n<\/ul>\n<p><strong>Publications, Presentations and Other Projects:<\/strong><\/p>\n<ul>\n<li><strong>Flatt,P.M. <\/strong>(In Preparation) <em>The Biochemistry of Integrative Medicine: An Evidence-Based Approach to Holistic Medicine. <\/em>CC BY-NC-SA.<\/li>\n<li>Abozenadah, H., Bishop, A., Bittner, S. and <strong>Flatt, P.M. <\/strong>(2018) <em>Chemistry and the Environment.<\/em> CC BY-NC-SA.\u00a0 Available at:<span>\u00a0<\/span><a href=\"https:\/\/wou.edu\/chemistry\/courses\/online-chemistry-textbooks\/3890-2\/\"><span>https:\/\/wou.edu\/chemistry\/courses\/online-chemistry-textbooks\/3890-2\/<\/span><\/a><\/li>\n<li>Abozenadah, H., Bishop, A., Bittner, S. and <strong>Flatt, P.M. <\/strong>(2017) <em>Preparatory Chemistry.<\/em> CC BY-NC-SA.\u00a0 Available at:<span>\u00a0<\/span><a href=\"https:\/\/wou.edu\/chemistry\/courses\/online-chemistry-textbooks\/ch150-preparatory-chemistry\/\"><span>https:\/\/wou.edu\/chemistry\/courses\/online-chemistry-textbooks\/ch150-preparatory-chemistry\/<\/span> <\/a><\/li>\n<li>Abozenadah, H., Bishop, A., Bittner, S., Lopez, O., Wiley, C., and <strong>Flatt, P.M.<\/strong> (2017) <em>Consumer Chemistry:\u00a0 How Organic Chemistry Impacts Our Lives.<\/em>\u00a0 CC BY-NC-SA.\u00a0 Available at: <a href=\"https:\/\/wou.edu\/chemistry\/courses\/online-chemistry-textbooks\/ch105-consumer-chemistry\/\"><span>https:\/\/wou.edu\/chemistry\/courses\/online-chemistry-textbooks\/ch105-consumer-chemistry\/<\/span><\/a><\/li>\n<li><strong>Flatt, P.M.,<\/strong> Damarjanan, C., Isamonger, E., Kalinski J.C., Dorrington, R.A., and McPhail, K.L. (2016). \u2018<em>Stromatolite microbial communities as a source of new bioactive secondary metabolites<\/em>\u2019. Poster Presentation at 9<sup>th<\/sup> Joint Natural Products Conference, Copenhagen, Denmark.<\/li>\n<li>Mahmud, T., Ito, T., <strong>Flatt, P.M.,<\/strong> Roongsawang, N. and Shirasaka, N. (Jan 2015) U.S. Patent: <em>Pactamycin Analogs and Methods of Making Thereof.<\/em><strong>\u00a0<\/strong><\/li>\n<li>Leingang, A., Taylor, B. Loper, J., Latham, K.L., and <strong>Flatt, P.M.<\/strong> (Nov 2015) Poster Presentation: <em>The role of secondary metabolite biosynthesis in the host-pathogen responses of Drosophila melanogaster to Pseudomonas sp. infection<\/em>. MJ Murdock College Science Research Conference \u2013 The ICIng on Undergraduate Research, Vancouver, WA.<\/li>\n<li>Participated as a Panel Member in an open forum discussion on, \u201cTai Chi and the Brain\u201d at the International Tai Chi Chaun Symposium on Health, Education and Cultural Exchange, July 6<sup>th<\/sup>-11<sup>th<\/sup>, 2014.<\/li>\n<li>Oral Presentation entitled, \u201cTai Chi Related Research on the Health of the Brain and Nervous System: Systematic Review and Meta-Analysis\u201d at the International Tai Chi Chaun Symposium on Health, Education and Cultural Exchange, July 6<sup>th<\/sup>-11<sup>th<\/sup>, 2014<\/li>\n<li>Poster Presentation entitled, \u201cResearch Collaboration on Host-Pathogen Interactions between <em>Drosophila<\/em> and <em>P. fluorescens <\/em>bacteria Builds Cross-Disciplinary and Cross-Institutional Collaborations \u201d Council on Undergraduate Research. Feb 2014.<\/li>\n<li><strong>Flatt, P.M.,<\/strong> Walters, M., Perry, S. and Mahmud, T. (2013) Genetic insights into pyralomicin biosynthesis in <em>Nonomuraea spiralis <\/em>IMC A-0156. <em>Journal of Natural Products <\/em>76(5):939-946.<\/li>\n<li>Zhang, L., Wang, J., Xu, B., and <strong>Flatt, P.M<\/strong>. (2012) Production of Bio-fuels by Enzyme-Catalyzed Hydrolysis of Cellulose. <em>Key Engineering Materials<\/em> 519:100-103.<\/li>\n<li>Asamizu, S., Xie, P., Brumsted, C., <strong>Flatt, P.M.,<\/strong> Mahmud, T. (2012) Evolutionary Divergence of Sedoheptulose 7-Phosphate Cyclases Leads to Several Distinct Cyclic Products. <em>JACS <\/em>134(29):12219-29<em>.<\/em><\/li>\n<li>Andrianasolo, E., <strong>Flatt, P.M.,<\/strong> McPhail, K.L., Simmons T. L., and Gerwick, W.H. (2011) Pivotal Connections: Tracing Support by the Natural Products Branch to Drug Discovery from Marine Organisms. Published in Bruce Ponman\u2019s Ed: <em>Realizing Natures Potential: Proceedings of the William L Brown Symposium Honoring Dr. Gordon Cragg. <\/em>MGB Press.<\/li>\n<li>Ito, T., Roongsawang, N., Shirasaka, N., Lu, W., <strong>Flatt, P.M.<\/strong>, Kasanah, N., Miranda, C., and Mahmud, T. (2009) Deciphering pactamycin biosynthesis and engineered production of new pactamycin analogues. <em>ChemBioChem.<\/em> 10: 2253-2265.<\/li>\n<li>Fosto, S., Zabriskie, T.M., Proteau, P.J., <strong>Flatt, P.M.<\/strong>, Santosa, D.A., Sulastri, and Mahmud, T. (2009) Limazepines A-F, Pyrrolo[1,4]benzodiazepine Antibiotics from an Indonesian <em>Micrococcus<\/em> sp. <em>J. Nat. Prod.<\/em> 72(4): 690-695.<\/li>\n<li>Wu, X.,<strong> Flatt, P.M.<\/strong>, and Mahmud, T. (2009) Biosynthetic gene cluster of Cetoniacytone A, an unusual aminocyclitol from the endosymbiotic bacterium, <em>Actinomyctes <\/em>sp. LU9419. <em>ChemBioChem <\/em>10(2):304-314.<\/li>\n<li>Mahmud, T., <strong>Flatt, P. M<\/strong>., and Wu, X. (2007) Biosynthesis of Unusual Aminocyclitol-containing Natural Products. <em>J. Nat. Prod.<\/em>, <em>70<\/em>, 1384-1391.<\/li>\n<li>Wu, X., <strong>Flatt, P.M.<\/strong>, Schlorke, O., Zeeck, A. Dairi, T., Mahmud, T. (2007) A comparative analysis of the sugar phosphate cyclase superfamily involved in primary and secondary metabolism. <em>Chembiochem.<\/em> 8(2):239-48.<\/li>\n<li><strong>Flatt, P.M.,<\/strong> Mahmud, T. (2007) Biosynthesis of aminocyclitol-aminoglycoside antibiotics and related compounds. <em>Nat Prod Rep<\/em>. 24(2):358-92.<\/li>\n<li>Ramaswamy, A.V., <strong>Flatt, P.M.,<\/strong> Edwards, D.J., Simmons, T.L., Han, B., Gerwick, W.H. (2006) \u201cThe secondary metabolites and biosynthetic gene clusters of marine cyanobacteria. Applications in biotechnology.\u201d In Proksch, P. and M\u00fcller, W.E.G. eds. of Frontiers of Marine Biotechnology. Horizon Scientific Press, Norfolk, UK.<\/li>\n<li><strong>Flatt,P.M., <\/strong>O\u2019Connell, S.J., McPhail, K., Zeller, G., Willis, C., Sherman, D.H. and Gerwick, W.H. (2006) Characterization of the Initial Steps in Barbamide Biosynthesis. <em>J. Nat. Prod<\/em>. 69(6):938-44.<\/li>\n<li><strong>Flatt, P.M.,<\/strong> Gautschi, J.T., Thacker, R.W., Musafija-Girt, M., Crews, P. and Gerwick, W.H. (2005) Identification of the Cellular Site of Polychlorinated Peptide Biosynthesis in the Marine Sponge <em>Dysidea<\/em> (<em>Lamellodysidea<\/em>) <em>herbacea<\/em> and Symbiotic Cyanobacterium <em>Oscillatoria spongeliae<\/em> by CARD-FISH analysis. <em>Marine Biology <\/em>147(3):761-774.<\/li>\n<li>Simmons, T.L., Andrianasolo, E., McPhail, K., <strong>Flatt, P.M.<\/strong> and Gerwick, W.H. (2005) Marine natural products as anticancer drugs.\u00a0\u00a0 <em>Molecular and Cancer Therapeutics<\/em>4:333-342.<\/li>\n<li>Chang, Z., Sitichitta, N., Rossi, J.V., Roberts, M.A., <strong>Flatt, P.M.,<\/strong> Jia, J., Sherman, D.H. and Gerwick, W.H. Biosynthetic pathway and gene cluster analysis of curacin A, an anti-tubulin natural product form the tropical marine cyanobacterium <em>Lyngbya majuscula<\/em>. <em>J Nat Prod <\/em>67(8):1356-67 (2004).<\/li>\n<li>Chang, Z*., <strong>Flatt, P.M.<\/strong>*., Gerwick, W.H., Nguyen, V-A., Willis, C.L., and Sherman, D.H. (2002). The barbamide biosynthetic gene cluster: A novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit. <em>Gene<\/em>. 296:235-247. *Authors with equal contribution to this work.<\/li>\n<li><strong>Flatt, P.M. <\/strong>and Pietenpol, J.A. (2000). Mechanisms of cell cycle checkpoints: At the crossroads of carcinogenesis and drug discovery. <em>Drug Metabolism Reviews<\/em>. 32(3&amp;4), 283-305.<\/li>\n<li><strong>Flatt, P.M., <\/strong>Tan, L. J., Scatena, C.D., Szak, S.T., Pietenpol, J.A., (2000). p53 regulation of G2 checkpoint is retinoblastoma protein dependent. <em>Mol Cell Biol<\/em> 20(12): 4210-4223.<\/li>\n<li><strong>Flatt, P.M<\/strong>., Polyak, K., Tang, L.J., Scatena, C.D., Westfall, M.D., Rubenstein, L.A., Yu, J., Kinzler, K. W., Vogelstein, B., Hill, D., and Pietenpol, J.A. (2000) p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest. <em>Cancer Letters<\/em> 156:63-72<\/li>\n<li><strong>Flatt, P.M<\/strong>., Price, J.O., Shaw, A., and Pietenpol, J.A. (1998). Differential cell cycle checkpoint response in normal human keratinocytes and fibroblasts. <em>Cell Growth and Differentiation.<\/em> 9:535-543.<\/li>\n<li>Herrmann, L.M., <strong>Flatt, P<\/strong>., and Bowler, B.E. (1996). Site-directed replacement of the invariant lysine73 of Saccharomyces cervisiae iso-1-cytochrome c with all ribosomally encoded amino acids. <em>Inorganica Chimica Acta<\/em>. 242(1):97-103.<\/li>\n<\/ul>\n<p><strong>Grants and Fellowships:<\/strong><\/p>\n<p><em>Pending:<\/em><\/p>\n<p><em>Current: <\/em><\/p>\n<p><em>Completed: <\/em><\/p>\n<ul>\n<li><strong>Flatt, P.M. (PI)<\/strong> (Feb 2017- Jan 2018) <em>\u2018Monitoring Freshwater Harmful Algal Blooms in the Pacific Northwest.\u2019<\/em> Funded By: WOU Faculty Development. $3,500.<\/li>\n<li><strong>Flatt, P.M (PI)<\/strong> (July 2017 \u2013 June 2018) <em>\u2018Open Source Learning Materials for Introductory Chemistry Coursework in General, Organic and Biochemistry: Meeting Education Needs from High School to College.<\/em>\u2018 Funded By: Higher Education Coordinating Commission. $26,725.<\/li>\n<li><strong>Flatt, P.M. (PI) <\/strong>and Monahan, Sue (Co-PI)<strong>. <\/strong>(May 2016 \u2013 June 2017). Collaborative Grant with Oregon State University. \u2018<em>Oregon Alliance for Minority Participation (OR AMP)<\/em><em>: <\/em><em>Diversifying Oregon\u2019s STEM workforce.\u2019<\/em> General Fund HB 3072. Funded by: Higher Education Coordinating Commission (HECC). $226,872.<\/li>\n<li><b>Flatt, P.M. (PI)<\/b> (Oct 2015 \u2013 Sept, 2016). Grant: \u2018<em>Building Bridges to STEM Education in the Mid-Willamette Valley.<\/em>\u2019 Funded by: Walmart Foundation. $40,000.<\/li>\n<li><strong>Flatt, P.M.<\/strong> Participating as a Vertical Leader in a five-year NSF funded grant entitled, \u2018ASAP \u2013 Advancing the careers of women in STEM at predominantly undergraduate institutions\u2019. PI: Joanne Smieja at Gonzaga University (2011-2016).<\/li>\n<li><strong>Flatt, P.M. (Co-PI)<\/strong> (Awarded 06\/01\/2011- 06\/01\/2013) Collaborative Grant Proposal Submitted with Steve Taylor (PI) and Paul Measeles (PI) at Oregon Department of Agriculture. \u2018Surface Water Quality Monitoring in the Mid-Willamette Valley.\u2019 Submitted to Oregon Watershed Enhancement Board (OWEB). $10,600.<\/li>\n<li><strong>Flatt, P.M. <\/strong>(Awarded 01\/01\/2011) Faculty Development Grant awarded by WOU. Deciphering Secondary Metabolic Pathways in Microorganisms. $3,000<\/li>\n<li><strong>Flatt, P.M., Latham, K. and Courtney, A<\/strong>. (April 2010) $9,500 grant award from WOU Academic Infrastructure Committee for the purchase of a shaker incubator.<\/li>\n<li><strong>Flatt, P.M., and Allen, W. <\/strong>(April 2010) $650 grant award from WOU Student Technology Committee for the development of distance learning resources.<\/li>\n<li><strong>Flatt, P.M.<\/strong> (Dec, 2008 \u2013 Dec, 2009) $500 grant award from WOU Foundation Grant entitled, \u2018Profiling Oregon Soil Microbes for Use in the Production of Biofuels and Medicines.\u2019<\/li>\n<li><strong>Flatt, P.M. <\/strong>(Jan, 2009 \u2013 June, 2010 ) $3,500 grant award from WOU Faculty Development entitled, \u2018The Biosynthesis of Photoprotective Mycosporine-like Amino Acids.\u2019<\/li>\n<li><strong>Flatt, P.M<\/strong>. (July 2007-June 2009) \u201cGenetic engineering of <em>Pseudomonas fluorescens<\/em> as biocontrol agents.\u201d Agricultural Research Foundation Grant. Grant amount: $12,000<\/li>\n<li><strong>Flatt, P.M. <\/strong>(May 2006 \u2013 April 2007) \u201cCharacterization of the pyralomicin halogenases for use in drug design.\u201d General Research Fund Grant from OSU. Grant amount: $10,000<\/li>\n<li><strong>Flatt, P.M. <\/strong>(Feb 2006-Feb 2007) \u201cMolecular Evolution of the Pyralomicin N-Glycosyltransferase for use in Drug Design.\u201d Medical Research Foundation of Oregon. Grant amount: $30,000<\/li>\n<li><strong>Flatt, P.M<\/strong>. and Gerwick, W.H., (Dec 2000 \u2013 Dec 2003) \u201cIsolation of halogenating enzymes for drug design.\u201d <em>NRSA-F32 NIH Postdoctoral Fellowship<\/em><\/li>\n<\/ul>\n<p><strong>Professional Associations:<\/strong><\/p>\n<ul>\n<li>American Society of Pharmacognosy (2008 \u2013 Present)<\/li>\n<li>Oregon Academy of Science (2008 \u2013 2010)<\/li>\n<li>Council on Undergraduate Research (2009 \u2013 2010)<\/li>\n<li>American Association of Cancer Research (1999-2000)<\/li>\n<li>International Society for the Study of Xenobiotics (1999-2000)<\/li>\n<\/ul>\n<p><strong>Synergistic Activities:<\/strong><\/p>\n<ul>\n<li>Over the last two years, I have started a new STEM Scholars Center on campus aimed to increase the recruitment and retentions of underrepresented and underserved student populations. This program has included outreach to local area high schools and the creation of an equipment rental program for high school chemistry classes to be able to engage students in hands-on laboratory activities.<\/li>\n<li>For the last five years, I have participated as a Vertical Leader in an NSF Advance Grant entitled, <em>Advancing the careers of women in STEM at predominantly undergraduate institutions<\/em>. The PI of this grant is Joanne Smieja at Gonzaga University. Participation in this program has allowed me to develop new leadership skills and enhance my undergraduate teaching skills, especially in the development of innovative ways to include undergraduate research in the classroom.<\/li>\n<li>I have developed of a new Faculty-Led Study Abroad Program in the Applications of Traditional Chinese Medicine (TCM). This program has successfully brought students to China in the summers of 2013 and 2015 to study the therapeutics of TCM.\u00a0 Two undergraduate students from this program are currently conducting natural products research within my laboratory.<\/li>\n<li>I have developed the Medicinal Chemistry and Pharmacology Emphasis Program in Chemistry at Western Oregon University. This program has helped to triple our enrolment of Undergraduate Chemistry Majors at WOU over the last three years and provides new opportunities for undergraduate students to conduct research within our department.<\/li>\n<li>Over the last 9 years, I have trained a total of 26 undergraduate students within my laboratory.<\/li>\n<\/ul>\n<h2>Courses Taught:<\/h2>\n<ul>\n<li><span style=\"color: #000000\">CH104, 105, 106 Introductory Chemistry Series (General-Organic-Biochemistry)<\/span><\/li>\n<li><span style=\"color: #000000\">CH320 Introduction to Forensic Science<\/span><\/li>\n<\/ul>\n<ul>\n<li><span style=\"color: #000000\">CH322 Medicinal Chemistry and Pharmacology<\/span><\/li>\n<li><span style=\"color: #000000\">CH345 Introduction to Toxicology<\/span><\/li>\n<li><span style=\"color: #000000\">CH347 Biochemistry of Complementary and Alternative Medicines<\/span><\/li>\n<li><span style=\"color: #000000\">CH420W Forensic Laboratory Techniques and Documentation<\/span><\/li>\n<li><span style=\"color: #000000\">CH445 Toxicology Laboratory Techniques<\/span><\/li>\n<li><span style=\"color: #000000\">CH450\/550 Biochemistry I<\/span><\/li>\n<li><span style=\"color: #000000\">CH450\/551 Biochemistry II<\/span><\/li>\n<li><span style=\"color: #000000\">CH452\/552 Biochemistry Lab<\/span><\/li>\n<\/ul>\n<h2><\/h2>\n<h2>Research Interests:<\/h2>\n<p><span style=\"color: #000000\">I am interested in studying the biological activities and biosynthesis of natural products in marine and terrestrial ecosystems.\u00a0 Current project in the lab, include:<\/span><\/p>\n<ul>\n<li><span style=\"color: #000000\">The investigation of insecticidal properties of <em>Pseudomonas fluorescens<\/em> on the developmental processes of <em>Drosophila melanogaster<\/em> larvae. <\/span><\/li>\n<li><span style=\"color: #000000\">The molecular mechanisms of casting behavior in the common bean, <em>Phaseolus vulgaris<\/em>.<\/span><\/li>\n<li><span style=\"color: #000000\">The isolation and characterization of soil bacteria with novel antibiotic properties.<\/span><\/li>\n<\/ul>\n<h2><\/h2>\n<h2>Curriculum Vitae:<\/h2>\n<p><span style=\"color: #000000\"><strong>Appointments:<\/strong><\/span><\/p>\n<ul>\n<li><span style=\"color: #000000\">Associate Professor (2008 to present) Department of Chemistry, Western Oregon University, Monmouth, OR<\/span><\/li>\n<li><span style=\"color: #000000\">Assistant Professor of Sr. Research (2003-2010) College of Pharmacy, Oregon State University, Corvallis, OR Education<\/span><\/li>\n<li><span style=\"color: #000000\">Postdoctoral Fellow, Marine Natural Products Research (2000-2003) College of Pharmacy, Oregon State University, Corvallis, OR.<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #000000\"><strong>Education:<\/strong><\/span><\/p>\n<ul>\n<li><span style=\"color: #000000\">Ph.D. in Biochemistry,Vanderbilt University,Nashville, TN. 1994-2000<\/span><\/li>\n<li><span style=\"color: #000000\">M.S. in Biology with an Emphasis in Plant Ecology, University of Denver, Denver, CO. 1992-1994<\/span><\/li>\n<li><span style=\"color: #000000\">Bachelor of Science in Biology at University of Denver, Denver, CO. Magna Cum Laude. Minors in Chemistry and Geography.1988-1992<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #000000\"><strong>Publications:<\/strong><\/span><\/p>\n<ul>\n<li><span style=\"color: #000000\"><span style=\"color: #000000\"><strong><\/strong><\/span><strong>Flatt,P.M. <\/strong>(In Preparation) <em>The Biochemistry of Integrative Medicine: An Evidence-Based Approach to Holistic Medicine. <\/em>Textbook in Preparation for Sentia Publishing.<span style=\"color: #000000\"><strong><\/strong><\/span><\/span><\/li>\n<li><span style=\"color: #000000\"><strong>Flatt, P.M.,<\/strong> Walters, M., Perry, S. and Mahmud, T. (2013) Genetic insights into pyralomicin biosynthesis in <em>Nonomuraea spiralis <\/em>IMC A-0156. <em>Journal of Natural Products <\/em>76(5):939-946.<\/span><\/li>\n<li><span style=\"color: #000000\">Zhang, L., Wang, J., Xu, B., and <strong>Flatt, P.M<\/strong>. (2012) Production of Bio-fuels by Enzyme-Catalyzed Hydrolysis of Cellulose. <em>Key Engineering Materials<\/em> 519:100-103.<\/span><\/li>\n<li><span style=\"color: #000000\">Asamizu, S., Xie, P., Brumsted, C., <strong>Flatt, P.M.,<\/strong> Mahmud, T. (2012) Evolutionary Divergence of Sedoheptulose 7-Phosphate Cyclases Leads to Several Distinct Cyclic Products. <em>JACS <\/em>134(29):12219-29<em>.<\/em><\/span><\/li>\n<li><span style=\"color: #000000\">Andrianasolo, E., <strong>Flatt, P.M.,<\/strong> McPhail, K.L., Simmons T. L., and Gerwick, W.H. (2011) Pivotal Connections: Tracing Support by the Natural Products Branch to Drug Discovery from Marine Organisms. Published in Bruce Ponman\u2019s Ed: <em>Realizing Natures Potential: Proceedings of the William L Brown Symposium Honoring Dr. Gordon Cragg. <\/em>MGB Press.<\/span><\/li>\n<li><span style=\"color: #000000\">Ito, T., Roongsawang, N., Shirasaka, N., Lu, W., <strong>Flatt, P.M.<\/strong>, Kasanah, N., Miranda, C., and Mahmud, T. (2009) Deciphering pactamycin biosynthesis and engineered production of new pactamycin analogues. <em>ChemBioChem.<\/em> 10: 2253-2265.<\/span><\/li>\n<li><span style=\"color: #000000\">Fosto, S., Zabriskie, T.M., Proteau, P.J., <strong>Flatt, P.M.<\/strong>, Santosa, D.A., Sulastri, and Mahmud, T. (2009) Limazepines A-F, Pyrrolo[1,4]benzodiazepine Antibiotics from an Indonesian <em>Micrococcus<\/em> sp. <em>J. Nat. Prod.<\/em> 72(4): 690-695.<\/span><\/li>\n<li><span style=\"color: #000000\">Wu, X.,<strong> Flatt, P.M.<\/strong>, and Mahmud, T. (2009) Biosynthetic gene cluster of Cetoniacytone A, an unusual aminocyclitol from the endosymbiotic bacterium, <em>Actinomyctes <\/em>sp. LU9419. <em>ChemBioChem <\/em>10(2):304-314.<\/span><\/li>\n<li><span style=\"color: #000000\">Mahmud, T., <strong>Flatt, P. M<\/strong>., and Wu, X. (2007) Biosynthesis of Unusual Aminocyclitol-containing Natural Products. <em>J. Nat. Prod.<\/em>, <em>70<\/em>, 1384-1391.<\/span><\/li>\n<li><span style=\"color: #000000\">Wu, X., <strong>Flatt, P.M.<\/strong>, Schlorke, O., Zeeck, A. Dairi, T., Mahmud, T. (2007) A comparative analysis of the sugar phosphate cyclase superfamily involved in primary and secondary metabolism. <em>Chembiochem.<\/em> 8(2):239-48.<\/span><\/li>\n<li><span style=\"color: #000000\"><strong>Flatt, P.M.,<\/strong> Mahmud, T. (2007) Biosynthesis of aminocyclitol-aminoglycoside antibiotics and related compounds. <em>Nat Prod Rep<\/em>. 24(2):358-92.<\/span><\/li>\n<li><span style=\"color: #000000\">Ramaswamy, A.V., <strong>Flatt, P.M.,<\/strong> Edwards, D.J., Simmons, T.L., Han, B., Gerwick, W.H. (2006) \u201cThe secondary metabolites and biosynthetic gene clusters of marine cyanobacteria. Applications in biotechnology.\u201d In Proksch, P. and M\u00fcller, W.E.G. eds. of Frontiers of Marine Biotechnology. Horizon Scientific Press, Norfolk, UK.<\/span><\/li>\n<li><span style=\"color: #000000\"><strong>Flatt,P.M., <\/strong>O\u2019Connell, S.J., McPhail, K., Zeller, G., Willis, C., Sherman, D.H. and Gerwick, W.H. (2006) Characterization of the Initial Steps in Barbamide Biosynthesis. <em>J. Nat. Prod<\/em>. 69(6):938-44.<\/span><\/li>\n<li><span style=\"color: #000000\"><strong>Flatt, P.M.,<\/strong> Gautschi, J.T., Thacker, R.W., Musafija-Girt, M., Crews, P. and Gerwick, W.H. (2005) Identification of the Cellular Site of Polychlorinated Peptide Biosynthesis in the Marine Sponge <em>Dysidea<\/em> (<em>Lamellodysidea<\/em>) <em>herbacea<\/em> and Symbiotic Cyanobacterium <em>Oscillatoria spongeliae<\/em> by CARD-FISH analysis. <em>Marine Biology <\/em>147(3):761-774.<\/span><\/li>\n<li><span style=\"color: #000000\">Simmons, T.L., Andrianasolo, E., McPhail, K., <strong>Flatt, P.M.<\/strong> and Gerwick, W.H. (2005) Marine natural products as anticancer drugs.\u00a0\u00a0 <em>Molecular and Cancer Therapeutics<\/em>4:333-342.<\/span><\/li>\n<li><span style=\"color: #000000\">Chang, Z., Sitichitta, N., Rossi, J.V., Roberts, M.A., <strong>Flatt, P.M.,<\/strong> Jia, J., Sherman, D.H. and Gerwick, W.H. Biosynthetic pathway and gene cluster analysis of curacin A, an anti-tubulin natural product form the tropical marine cyanobacterium <em>Lyngbya majuscula<\/em>. <em>J Nat Prod <\/em>67(8):1356-67 (2004).<\/span><\/li>\n<li><span style=\"color: #000000\">Chang, Z*., <strong>Flatt, P.M.<\/strong>*., Gerwick, W.H., Nguyen, V-A., Willis, C.L., and Sherman, D.H. (2002). The barbamide biosynthetic gene cluster: A novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit. <em>Gene<\/em>. 296:235-247. *Authors with equal contribution to this work.<\/span><\/li>\n<li><span style=\"color: #000000\"><strong>Flatt, P.M. <\/strong>and Pietenpol, J.A. (2000). Mechanisms of cell cycle checkpoints: At the crossroads of carcinogenesis and drug discovery. <em>Drug Metabolism Reviews<\/em>. 32(3&amp;4), 283-305.<\/span><\/li>\n<li><span style=\"color: #000000\"><strong>Flatt, P.M., <\/strong>Tan, L. J., Scatena, C.D., Szak, S.T., Pietenpol, J.A., (2000). p53 regulation of G2 checkpoint is retinoblastoma protein dependent. <em>Mol Cell Biol<\/em> 20(12): 4210-4223.<\/span><\/li>\n<li><span style=\"color: #000000\"><strong>Flatt, P.M<\/strong>., Polyak, K., Tang, L.J., Scatena, C.D., Westfall, M.D., Rubenstein, L.A., Yu, J., Kinzler, K. W., Vogelstein, B., Hill, D., and Pietenpol, J.A. (2000) p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest. <em>Cancer Letters<\/em> 156:63-72<\/span><\/li>\n<li><span style=\"color: #000000\"><strong>Flatt, P.M<\/strong>., Price, J.O., Shaw, A., and Pietenpol, J.A. (1998). Differential cell cycle checkpoint response in normal human keratinocytes and fibroblasts. <em>Cell Growth and Differentiation.<\/em> 9:535-543.<\/span><\/li>\n<li><span style=\"color: #000000\">Herrmann, L.M., <strong>Flatt, P<\/strong>., and Bowler, B.E. (1996). Site-directed replacement of the invariant lysine73 of Saccharomyces cervisiae iso-1-cytochrome c with all ribosomally encoded amino acids. <em>Inorganica Chimica Acta<\/em>. 242(1):97-103.<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000\"><strong>Scholarly Presentations\/Workshops:<\/strong><strong><\/strong><\/span><\/p>\n<ul>\n<li><span style=\"color: #000000\">Participated as a Panel Member in an open forum discussion on, \u201cTai Chi and the Brain\u201d at the International Tai Chi Chaun Symposium on Health, Education and Cultural Exchange, July 6<sup>th<\/sup>-11<sup>th<\/sup>, 2014.<\/span><\/li>\n<li><span style=\"color: #000000\">Oral Presentation entitled, \u201cTai Chi Related Research on the Health of the Brain and Nervous System: Systematic Review and Meta-Analysis\u201d at the International Tai Chi Chaun Symposium on Health, Education and Cultural Exchange, July 6<sup>th<\/sup>-11<sup>th<\/sup>, 2014<\/span><\/li>\n<li><span style=\"color: #000000\">Poster Presentation entitled, &#8220;Research Collaboration on Host-Pathogen Interactions between <em>Drosophila<\/em> and <em>P. fluorescens <\/em>bacteria Builds Cross-Disciplinary and Cross-Institutional Collaborations &#8221; Council on Undergraduate Research. Feb 2014.<\/span><\/li>\n<li><span style=\"color: #000000\">Poster Presentation entitled, &#8220;Isolation of Halogenated Metabolites from <em>Frankia alni<\/em>&#8221; American Society of Pharmacognosy Annual Meeting, 2011.<\/span><\/li>\n<li><span style=\"color: #000000\">Oral Presentation entitled, \u201cIdentification and Functional Analysis of the Pyralomicin Biosynthetic Gene Cluster.\u201d Presented at the 69<sup>th<\/sup> Annual Meeting of the Oregon Academy of Science, Concordia University, Portland, OR. Feb 27<sup>th<\/sup>, 2010<\/span><\/li>\n<li><span style=\"color: #000000\">Proposal Writing Institute sponsored by the Council on Undergraduate Research. Salem, OR, July 12-23, 2009.<\/span><\/li>\n<li><span style=\"color: #000000\">Poster Presentation entitled, \u201cCharacterization of the Pyralomicin Biosynthetic Gene Cluster,\u201d presented at the 50<sup>th<\/sup> Anniversary Meeting of the American Society of Pharmacognosy. Honolulu, HI, June 27-July 1<sup>st<\/sup>, 2009.<\/span><\/li>\n<li><span style=\"color: #000000\">Oral Presentation entitled, \u201cUse of genome mining to identify the biosynthetic genes involved in mycosporine-like amino acid biosynthesis,\u201d presented at the 68<sup>th<\/sup> Annual Meeting of the Oregon Academy of Science, Monmouth, OR, Feb, 28<sup>th<\/sup>, 2009.<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000\"><strong>Grants and Fellowships:<\/strong><\/span><\/p>\n<p><span style=\"color: #000000\"><em>Pending:<\/em><\/span><\/p>\n<ul>\n<li><span><span style=\"color: #000000\"><strong>Flatt, P.M. (Co-PI)<\/strong> (Submitted to the Oregon Watershed Enhancement Board) <\/span><\/span><span><span style=\"color: #000000\">$14,000. <\/span><\/span><span><span style=\"color: #000000\">Collaborative Grant Proposal Submitted with Marc Bell at the Polk County Soil and Water Conservation District. \u2018Surface Water Quality Monitoring in the Mid-Willamette Valley.\u2019<br \/>\n<\/span><\/span><\/li>\n<\/ul>\n<p><span style=\"color: #000000\"><em>Current:<\/em><\/span><\/p>\n<ul>\n<li><span style=\"color: #000000\"><strong>Flatt, P.M. (PI) <\/strong>Walmart Foundation Grant $40,000 Building Bridges to STEM Education in the Mid-Willamette Valley: Providing College-Level Laboratory Experiences in the High School Chemistry Classroom. (2015-2016).<\/span><\/li>\n<li><span style=\"color: #000000\">Participating as a Vertical Leader in a five-year NSF funded grant entitled, \u2018ASAP \u2013 Advancing the careers of women in STEM at predominantly undergraduate institutions\u2019. PI: Joanne Smieja at Gonzaga University (2011-2016).<\/span><\/li>\n<li><span style=\"color: #000000\"><strong>Flatt, P.M.<\/strong> WOU Foundation Grant $3,500 The Molecular Basis of Casting Behavior in the Common Bean, Phaseolus vulgaris. (2015)<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #000000\"><em>Completed: <\/em><\/span><\/p>\n<ul>\n<li><span style=\"color: #000000\"><strong>Flatt, P.M. (Co-PI)<\/strong> (Awarded 06\/01\/2011- 06\/01\/2013) Collaborative Grant Proposal Submitted with Steve Taylor (PI) and Paul Measeles (PI) at Oregon Department of Agriculture. \u2018Surface Water Quality Monitoring in the Mid-Willamette Valley.\u2019 Submitted to Oregon Watershed Enhancement Board (OWEB). $10,600.<\/span><\/li>\n<li><span style=\"color: #000000\"><strong>Flatt, P.M. <\/strong>(Awarded 01\/01\/2011) Faculty Development Grant awarded by WOU. Deciphering Secondary Metabolic Pathways in Microorganisms. $3,000<\/span><\/li>\n<li><span style=\"color: #000000\"><strong>Flatt, P.M., Latham, K. and Courtney, A<\/strong>. (April 2010) $9,500 grant award from WOU Academic Infrastructure Committee for the purchase of a shaker incubator.<\/span><\/li>\n<li><span style=\"color: #000000\"><strong>Flatt, P.M., and Allen, W. <\/strong>(April 2010) $650 grant award from WOU Student Technology Committee for the development of distance learning resources.<\/span><\/li>\n<li><span style=\"color: #000000\"><strong>Flatt, P.M.<\/strong> (Dec, 2008 \u2013 Dec, 2009) $500 grant award from WOU Foundation Grant entitled, \u2018Profiling Oregon Soil Microbes for Use in the Production of Biofuels and Medicines.\u2019<\/span><\/li>\n<li><span style=\"color: #000000\"><strong>Flatt, P.M. <\/strong>(Jan, 2009 \u2013 June, 2010 ) $3,500 grant award from WOU Faculty Development entitled, \u2018The Biosynthesis of Photoprotective Mycosporine-like Amino Acids.\u2019<\/span><\/li>\n<li><span style=\"color: #000000\"><strong>Flatt, P.M<\/strong>. (July 2007-June 2009) \u201cGenetic engineering of <em>Pseudomonas fluorescens<\/em> as biocontrol agents.\u201d Agricultural Research Foundation Grant. Grant amount: $12,000<\/span><\/li>\n<li><span style=\"color: #000000\"><strong>Flatt, P.M. <\/strong>(May 2006 \u2013 April 2007) \u201cCharacterization of the pyralomicin halogenases for use in drug design.\u201d General Research Fund Grant from OSU. Grant amount: $10,000<\/span><\/li>\n<li><span style=\"color: #000000\"><strong>Flatt, P.M. <\/strong>(Feb 2006-Feb 2007) \u201cMolecular Evolution of the Pyralomicin N-Glycosyltransferase for use in Drug Design.\u201d Medical Research Foundation of Oregon. Grant amount: $30,000<\/span><\/li>\n<li><span style=\"color: #000000\"><strong>Flatt, P.M<\/strong>. and Gerwick, W.H., (Dec 2000 \u2013 Dec 2003) \u201cIsolation of halogenating enzymes for drug design.\u201d <em>NRSA-F32 NIH Postdoctoral Fellowship<\/em><\/span><\/li>\n<\/ul>\n<p><span style=\"color: #000000\"><strong>Professional Associations:<\/strong><\/span><\/p>\n<ul>\n<li><span style=\"color: #000000\">American Society of Pharmacognosy (2008 \u2013 Present)<\/span><\/li>\n<li><span style=\"color: #000000\">American Chemical Society (2014 \u2013 Present)<\/span><\/li>\n<li><span style=\"color: #000000\">Oregon Academy of Science (2008 \u2013 2010)<\/span><\/li>\n<li><span style=\"color: #000000\">Council on Undergraduate Research (2009 \u2013 2010)<\/span><\/li>\n<li><span style=\"color: #000000\">American Association of Cancer Research (1999-2000)<\/span><\/li>\n<li><span style=\"color: #000000\">International Society for the Study of Xenobiotics (1999-2000)<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Professor of Chemistry Contact Department of Chemistry (503) 838-8644 | e-mail: flattp@wou.edu | DFSC 209 Courses Taught: CH104, 105, 106 Introductory Chemistry Series (General-Organic-Biochemistry) CH320 Introduction to Forensic Science CH322 Medicinal Chemistry and Pharmacology CH345 Introduction to Toxicology CH347 Integrative Medicinal Science CH420W Forensic Laboratory Techniques and Documentation CH445 Toxicology Laboratory Techniques CH450\/550 Biochemistry I [&hellip;]<\/p>\n","protected":false},"author":280,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_lmt_disableupdate":"","_lmt_disable":"","_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-1307","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/wou.edu\/chemistry\/wp-json\/wp\/v2\/pages\/1307","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wou.edu\/chemistry\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/wou.edu\/chemistry\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/wou.edu\/chemistry\/wp-json\/wp\/v2\/users\/280"}],"replies":[{"embeddable":true,"href":"https:\/\/wou.edu\/chemistry\/wp-json\/wp\/v2\/comments?post=1307"}],"version-history":[{"count":0,"href":"https:\/\/wou.edu\/chemistry\/wp-json\/wp\/v2\/pages\/1307\/revisions"}],"wp:attachment":[{"href":"https:\/\/wou.edu\/chemistry\/wp-json\/wp\/v2\/media?parent=1307"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}